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nifedipine will boost the amount or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.apalutamide will lessen the extent or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with drugs